Semax

Description

Semax (MEHFPGP) is a neuropeptide derived from the sequence Met–His–Phe–Pro–Gly–Pro-Arg, closely related to the (4-10) segment of adrenocorticotropic hormone (ACTH). This is a research compound for laboratory use only. Not for human consumption.

Research Dosage: Semax dosage used in research protocols typically ranges from 3 to 70 mcg/kg of body weight, adapted to specific study objectives. Due to regulatory and licensing constraints, specific indications or recommendations for its use or research practices outside controlled scientific contexts cannot be provided.

1. Dolotov, OV, et al. Semax, an ACTH(4–10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochemical Research, 2006.

2. Eremin, KO, et al. Semax, an analog of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. Journal of Neuroscience Research, 2006.

3. Kravkov, NP, et al. Effects of heptapeptide semax on dopaminergic and serotoninergic systems of the rat brain. Pharmacology, Biochemistry and Behavior, 2009.

4. Ashmarin, IP, et al. Semax, an analogue of adrenocorticotropin (4-7), is a potential agent for the of attention-deficit hyperactivity and Rett. Neuropsychopharmacology, 2006.

5. Manchenko, DM, et al. Effect of semax on the activity and emotional behavior of rats. Bulletin of Experimental Biology and Medicine, 2013.

6. Medvedev, VE, et al. Effects of Semax and Its C-Terminal Fragment Pro-Gly-Pro on the Morphofunctional State of Rat Hippocampus during Experimental Alzheimer’s. Journal of Alzheimer’s, 2018.

7. Sobolevsky, T, et al. Effects of semax and its C-terminal fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity. Biochemical Pharmacology, 2002.

Please note that while numerous research studies involve Semax, the FDA has not approved its use outside of controlled scientific studies. This product is intended exclusively for scientific research laboratory use and is not for human consumption.