Leírás

Product Description: PNC-27 10 mg Lyophilized Peptide Powder

Adagolás és tartalom:
– Forma: Lyophilized peptide powder
– Content per vial: 10 mg PNC-27
– Csomagolás: Glass vial with sterile closure

Tárolási útmutató:
– Store lyophilized at 2–8 °C (desiccated, protect from light)

Molecular Information:
– Molecular Formula: ( C_{214}H_{362}N_{70}O_{50} ) (Representative)
– Molecular Weight: ~4747.4 g·mol⁻¹ (Representative)
– CAS-szám: N/A (Structure Specific)

Sequence Structure:
– Összetétel: (Membrane Residue Penetrating Sequence)-Linker-(p53 HDM2-Binding Domain Sequence)
– Example sequence: RQIKIWFQNRRMKWKK-GGGSG-KKETLSPDDVQRE

Testing:
– This product underwent third-party testing to ensure quality and reliability.
– Each batch is tested for purity and efficacy.

Research Use Only:
– Jogi nyilatkozat: All products, including PNC-27, are intended exclusively for laboratory and scientific research. They are not for human or veterinary use.

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Overview of PNC-27

What is PNC-27?
PNC-27 is a synthetic peptide construct developed for anti-cancer research. It combines:
1. A peptide sequence that corresponds to the HDM-2 (MDM2 in rodents) binding domain of the p53 tumor suppressor protein.
2. A membrane-penetrating peptide sequence to enable cellular entry.

The primary aim of PNC-27 is to selectively target HDM-2/MDM2 proteins, which are frequently overexpressed and found on the cell membranes of various cancer types. This peptide has been researched for its ability to induce cell lysis through mechanisms like necrosis or apoptosis in cancer cells while sparing normal cells.

Research Implications

PNC-27 has significant implications in laboratory studies focused on:
– Targeting membrane-bound HDM-2/MDM2 in cancer cells.
– Inducing cancer cell death through apoptosis/necrosis.
– Achieving selective cytotoxicity towards cancer cells, differentiating them from normal cells.
– Exploring mechanisms involving p53 pathways and disruption of cellular membranes.
– Investigating various cancer models including pancreatic, breast, and leukemia.

További információ:

• For diluting the lyophilized peptide powder, it is recommended to use a solution such as bacteriostatic water (10 ml).
• Figyelmeztetés: This product is not intended for human or veterinary use and cannot be used as food, dietary supplements, or medicine. The information provided is for educational purposes only and does not constitute medical or other advice.

Assurance of Quality

• Limitless Biochem is recognized as a reliable supplier of research compounds that adhere to rigorous quality standards compliant with EU regulations. Their offerings, including PNC-27, are exclusively pure without additives and are thoroughly tested by independent laboratories.

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Jegyzet: This product is currently out of stock, and orders can be placed for future availability. Ensure to keep updated on restocking by checking back regularly.

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Key Ingredients and Scientific References

Hozzávaló	Leírás	Tudományos Referencia
Panax Ginseng	A well-known adaptogen that may help with energy and immune function.	Zhang, Q., et al. (2005). “Panax ginseng: a review of its potential as an anti-cancer and cardioprotective agent.” PubMed.
Kurkumin	Active compound of turmeric with anti-inflammatory and antioxidant properties.	Aggarwal, B. B., et al. (2009). “Curcumin: the Indian solid gold.” PubMed.
Alpha-Lipoic Acid	A potent antioxidant that may aid in metabolic health and neuroprotection.	Packer, L., et al. (1995). “Alpha-lipoic acid: a rainbow of functions.” PubMed.
Coenzyme Q10	A nutrient that plays a critical role in energy production and has antioxidant properties.	Hargreaves, I. P., et al. (2005). “Coenzyme Q10 and Heart Failure.” PubMed.
Cink	An essential mineral important for immune function and enzyme reactions.	Prasad, A. S. (2008). “Zinc: role in immunity, oxidative stress, and chronic inflammation.” PubMed.

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